- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
AMPK alpha 2 Antibody (F50190)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F50190-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 399 | |
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F50190-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 185 |
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| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse |
| Format | Purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Purified |
| UniProt | P54646 |
| Applications | Western blot : 1:1000 |
| Limitations | This AMPK alpha 2 antibody is available for research use only. |
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AMPK alpha 2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). It acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. [UniProt]
Titration of the AMPK alpha 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 476-507 from the human protein was used as the immunogen for this AMPK alpha 2 antibody.
Aliquot the AMPK alpha 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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