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Home >> Antibodies >> AMPK alpha 2 Antibody

AMPK alpha 2 Antibody (F50190)

  Catalog No Formulation Size Price (USD)  
Image F50190-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F50190-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
Western blot analysis of AMPK alpha 2 antibody and mouse heart tissue lysate
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt P54646
Applications Western blot : 1:1000
Limitations This AMPK alpha 2 antibody is available for research use only.
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Description

AMPK alpha 2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). It acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. [UniProt]

Application Notes

Titration of the AMPK alpha 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 476-507 from the human protein was used as the immunogen for this AMPK alpha 2 antibody.

Storage

Aliquot the AMPK alpha 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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