- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
AMD1 Antibody / Adenosylmethionine Decarboxylase 1 Antibody (R32969)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R32969 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P17707 |
| Localization | Cytoplasmic |
| Applications | Western Blot : 0.5-1ug/ml |
| Limitations | This AMD1 Antibody / Adenosylmethionine Decarboxylase 1 Antibody is available for research use only. |
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AMD1 Antibody / Adenosylmethionine Decarboxylase 1 Antibody detects AMD1, the enzyme responsible for producing decarboxylated S-adenosylmethionine, the essential aminopropyl donor required for polyamine biosynthesis. By catalyzing this rate-limiting step, AMD1 supports the synthesis of spermidine and spermine, polyamines that are critical for cell growth, nucleic acid function, protein synthesis and cellular homeostasis. Because polyamine metabolism is fundamental to normal physiology and disease, AMD1 Antibody / Adenosylmethionine Decarboxylase 1 Antibody is widely used in studies of cell proliferation, metabolism and cancer biology.
AMD1 is a highly regulated cytosolic enzyme whose activity is controlled at the transcriptional, translational and post-translational levels. Cellular polyamine concentrations influence AMD1 expression through feedback mechanisms that maintain metabolic balance while supporting normal growth and differentiation. The enzyme functions immediately downstream of S-adenosylmethionine synthesis, linking methionine metabolism with polyamine production and numerous biosynthetic pathways. Through its central position in cellular metabolism, AMD1 influences DNA replication, RNA processing, chromatin organization and protein translation. AMD1 Antibody / Adenosylmethionine Decarboxylase 1 Antibody provides an important tool for investigating these interconnected metabolic processes.
Increased AMD1 activity has been reported in many human cancers, including prostate, colorectal, liver and gastric carcinomas, where enhanced polyamine biosynthesis supports rapid cellular proliferation and tumor progression. Elevated polyamine metabolism has also been associated with oncogene activation, altered cellular differentiation and resistance to apoptosis. As a result, AMD1 has become an important therapeutic target, and inhibitors of polyamine biosynthesis continue to be investigated for their potential in cancer treatment. Analysis of AMD1 expression has therefore become valuable for understanding tumor metabolism and evaluating metabolic vulnerabilities in proliferating cells.
Beyond oncology, AMD1 contributes to normal embryonic development, tissue regeneration and immune cell function by regulating intracellular polyamine availability. The enzyme also participates in metabolic adaptations to cellular stress and changing nutritional conditions, highlighting its importance in maintaining physiological homeostasis. Ongoing research continues to define additional links between AMD1 activity, metabolic signaling networks and age-related diseases, expanding interest in this enzyme across multiple areas of biomedical research.
NSJ Bioreagents offers AMD1 Antibody / Adenosylmethionine Decarboxylase 1 Antibody products for researchers studying polyamine metabolism, cellular proliferation and metabolic regulation. These antibodies support applications including Western blot, immunohistochemistry, immunofluorescence, immunoprecipitation and flow cytometry for analysis of AMD1 expression and localization. AMD1 Antibody / Adenosylmethionine Decarboxylase 1 Antibody provides a valuable tool for investigating polyamine biosynthesis, metabolic reprogramming and disease-associated alterations in cellular growth and metabolism.
Researchers investigating polyamine metabolism, metabolic regulation and tumor biology may also be interested in our Cancer Antibodies page, featuring antibodies against metabolic enzymes, signaling proteins and other biomarkers involved in cancer progression and therapeutic research.
Optimal dilution of the AMD1 Antibody / Adenosylmethionine Decarboxylase 1 Antibody should be determined by the researcher.
Amino acids RKNFMKPSHQGYPHRNFQEEIEFLNA were used as the immunogen for the AMD1 antibody.
After reconstitution, the AMD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
S-Adenosylmethionine Decarboxylase 1 antibody, SAMDC antibody, AdoMetDC antibody, Adenosylmethionine Decarboxylase antibody, S-Adenosylmethionine Decarboxylase antibody, AMD1 Protein antibody
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