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Home >> Antibodies >> AMD1 Antibody / S-adenosylmethionine decarboxylase

AMD1 Antibody / S-adenosylmethionine decarboxylase (R30251)

  Catalog No Formulation Size Price (USD)  
Image R30251 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of AMD1 antibody and lysate from 1) rat kidney and 2) human HeLa cells. Predicted molecular weight ~38 kDa.
IHC-P: AMD1 antibody testing of human breast cancer tissue
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P17707
Localization Cytoplasmic
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This AMD1 antibody is available for research use only.
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Description

S-adenosylmethionine decarboxylase (AdoMet-DC), also known as S-adenosylmethionine decarboxylase proenzyme (SAMDC), is a key enzyme in polyamine biosynthesis. It is localized to chromosome region 6q21-q22. SAMDC has an unusual distribution in polysomes from cells of T lymphocyte origin. It associates predominantly with monosomes and small polysomes with none located in the preribosomal or ribonucleoprotein pool. SAMDC is a critical regulatory enzyme of the polyamine synthetic pathway, and a well-studied drug target. Since SAMDC is a key regulatory enzyme in the synthesis of spermidine and spermine, the marked increase in SAMDC activity in the neonate and the sustained high enzyme levels throughout adulthood, imply a role for these polyamines in both development and mature brain function.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the AMD1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of human AMD1 (FNDYNFVFTSFAKKQQ) was used as the immunogen for this AMD1 antibody (100% homologous in human, mouse and rat).

Storage

After reconstitution, the AMD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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