- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
AMACR Antibody (Prostate Cancer Marker) [clone AMACR/1723] (V3237)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3237-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
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V3237-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
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V3237SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, lambda |
| Clone Name | AMACR/1723 |
| Purity | Protein G affinity chromatography |
| UniProt | Q9UHK6 |
| Localization | Cytoplasmic |
| Applications | Western Blot : 0.5-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This AMACR antibody is available for research use only. |
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AMACR antibody is an essential reagent for examining alpha methylacyl CoA racemase, a peroxisomal and mitochondrial enzyme that plays a central role in fatty acid metabolism. AMACR catalyzes the racemization of alpha methyl branched chain fatty acyl CoA esters, allowing their subsequent degradation via beta oxidation. This enzyme is critical for metabolizing both dietary branched chain fatty acids and bile acid intermediates, underscoring its importance in energy and lipid homeostasis.
Mutations in the AMACR gene have been linked to rare metabolic disorders characterized by accumulation of branched chain fatty acids, leading to neurological dysfunction and other systemic symptoms. Beyond inherited disease, AMACR has garnered attention for its role in oncology. Overexpression of AMACR is a consistent feature of prostate carcinoma and has been observed in other malignancies, including renal cell carcinoma and colorectal cancer. This expression profile has made AMACR a useful marker in diagnostic pathology and a focus of cancer metabolism research.
The AMACR antibody clone AMACR/1723 provides dependable detection of this metabolic enzyme in both normal and diseased tissues. Clone AMACR/1723 has been used to confirm elevated AMACR expression in prostate tumors, aiding in the distinction of malignant from benign lesions. Its specificity ensures clear labeling of target epitopes, making it a reliable choice for investigating the metabolic adaptations associated with tumorigenesis.
AMACR continues to be studied as a biomarker for cancer progression and as a potential therapeutic target. By linking fatty acid metabolism with tumor growth, this enzyme highlights the connections between metabolic reprogramming and malignancy. Research into AMACR expression also informs investigations into fatty acid disorders and peroxisomal dysfunction, where altered enzyme activity disrupts normal metabolic balance. The consistent performance of clone AMACR/1723 makes it a trusted reagent across these research areas.
NSJ Bioreagents offers this AMACR antibody to support work in cancer biology, metabolism, and genetic disease. Researchers may also find this protein referred to as alpha methylacyl CoA racemase antibody, racemase antibody, RM antibody, and AMACR1 antibody. These alternate names are used in different research communities but all point to the same critical enzyme involved in branched chain fatty acid catabolism and tumor biology.
Optimal dilution of the AMACR antibody should be determined by the researcher.
A recombinant human protein was used as the immunogen for the AMACR antibody.
Store the AMACR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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