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Home >> Antibodies >> AMACR Antibody

AMACR Antibody (F40477)

  Catalog No Formulation Size Price (USD)  
Image F40477-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F40477-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
AMACR antibody western blot analysis in MDA-MB231 lysate. Predicted molecular weight ~43kDa.
AMACR antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma.
AMACR antibody flow cytometric analysis of MDA-MB231 cells (green) compared to a negative control (blue). FITC-conjugated goat-anti-rabbit secondary Ab was used for the analysis.
Confocal immunofluorescent analysis of AMACR antibody with HepG2 cells followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used as a nuclear counterstain (blue).
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q9UHK6
Applications Western blot : 1:1000
IHC (Paraffin) : 1:50-1:100
Flow Cytometry : 1:10-1:50
Immunofluorescence : 1:10-1:50
Limitations This AMACR antibody is available for research use only.
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Description

This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.

Application Notes

Titration of the AMACR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 323-351 from the human protein was used as the immunogen for this AMACR antibody.

Storage

Aliquot the AMACR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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