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Home >> Antibodies >> AMACR Antibody

AMACR Antibody [clone 2MACR-1] (V3990)

  Catalog No Formulation Size Price (USD)  
V3990-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 429

V3990-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 199

V3990SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 429

V3990IHC-7ML Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* 7 ml 429
Western blot testing of human kidney lysate with AMACR antibody (clone 2MACR-1). Predicted molecular weight ~43 kDa.
IHC testing of FFPE human prostate carcinoma with AMACR antibody (clone 2MACR-1). Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
Availability 1-3 business days
Species Reactivity Human. Other species not known.
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name 2MACR-1
Purity Protein G affinity chromatography
UniProt Q9UHK6
Localization Cytoplasmic
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 1-2ug/ml for 30 min at RT
Prediluted IHC only format : incubate for 30 min at RT (1)
Limitations This AMACR antibody is available for research use only.
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Description

The AMACR gene encodes the racemase Alpha-methylacyl-CoA. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [RefSeq]

Application Notes

Optimal dilution of the AMACR antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Immunogen

A portion of amino acids 297-394 was used as the immunogen for the AMACR antibody.

Storage

Store the AMACR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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