- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Alpha Tubulin (acetyl K40) Antibody / TUBA1B/TUBA4A [clone 31T79] (FY12718)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12718 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 439 |
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Alpha Tubulin (acetyl K40) antibody detects alpha tubulin specifically when acetylated at lysine 40. Alpha tubulin, encoded by multiple genes including TUBA1A, TUBA3C, and TUBA4A, is one of the two principal subunits of microtubules, the dynamic cytoskeletal polymers critical for cell shape, intracellular transport, and mitotic spindle formation. Common alternate identifiers include TUBA1 and TUBA4, which are widely referenced in literature. Acetylation of lysine 40 is a well known post translational modification associated with stable, long lived microtubules that support transport and signaling.
Alpha Tubulin (acetyl K40) antibody is widely applied in cell biology, neurobiology, and cancer research. Microtubule acetylation is enriched in neuronal axons, cilia, and stable cytoskeletal structures. By detecting acetylation at lysine 40, researchers can evaluate how microtubules achieve stability and how post translational modifications regulate cytoskeletal dynamics.
The antibody is validated for immunofluorescence, immunohistochemistry, and western blotting. Immunofluorescence with Alpha Tubulin (acetyl K40) antibody highlights stable microtubule tracks in neurons and ciliated cells. Immunohistochemistry maps tissue regions enriched in acetylated tubulin, while western blotting detects the modified isoform as distinct from total tubulin. These assays provide powerful tools for studying cytoskeletal regulation.
Acetylation at lysine 40 is mediated by alpha tubulin acetyltransferase (ATAT1) and reversed by histone deacetylase 6. Dysregulation of this balance contributes to neurodegenerative disease, cancer, and ciliopathies. By applying this phospho specific antibody, scientists can examine mechanisms of axonal transport, sensory signaling, and tumor progression.
Alpha Tubulin (acetyl K40) antibody from NSJ Bioreagents provides strong specificity for detecting this critical post translational modification. Its performance supports both basic and translational studies of microtubule biology.
Optimal dilution of the Alpha Tubulin (acetyl K40) antibody should be determined by the researcher.
A synthesized peptide derived from human alpha Tubulin (acetyl K40) was used as the immunogen for the Alpha Tubulin (acetyl K40) antibody.
Store the Alpha Tubulin (acetyl K40) antibody at -20oC.
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