Alpha-Synuclein Antibody / SNCA [clone AGA-19] (RQ8886)

Description

Alpha-Synuclein (SCNA) is a small, soluble protein predominantly expressed in the brain, particularly in presynaptic nerve terminals. It plays a role in synaptic vesicle trafficking, neurotransmitter release regulation, and neuronal plasticity. Alpha-Synuclein can adopt different conformations, with certain aggregated forms being implicated in neurodegenerative processes.

Mutations or abnormal accumulation of Alpha-Synuclein are strongly linked to synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Its aggregation into insoluble fibrils is a key pathological hallmark of these conditions. Studying Alpha-Synuclein expression and distribution provides valuable insights into neuronal function, protein misfolding, and neurodegenerative disease mechanisms.

Using a high-quality Alpha-Synuclein antibody enables sensitive detection in assays such as western blot, immunohistochemistry, and ELISA. An Alpha-Synuclein antibody from NSJ Bioreagents offers reliable performance for researchers investigating protein aggregation, neurodegenerative disease progression, and potential therapeutic interventions. Selecting the appropriate Alpha-Synuclein antibody is essential for generating reproducible and accurate results in both basic and applied neuroscience research.

Application Notes

Optimal dilution of the Alpha-Synuclein antibody should be determined by the researcher.

Immunogen

A peptide sequence specific to Alpha-Synuclein was used as the immunogen for the Alpha-Synuclein antibody.

Storage

After reconstitution, the Alpha-Synuclein antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.