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Home >> Antibodies >> Alpha Lactalbumin Antibody [Discontinued, view alternatives]

Alpha Lactalbumin Antibody [Discontinued, view alternatives] (R30797)

  Catalog No Formulation Size Price (USD)  
Image R30797 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 299
Western blot testing of alpha Lactalbumin antibody and Lane 1: MCF-7; 2: MM231; 3: MM453; 4: HeLa cell lysate
IHC-P: alpha Lactalbumin antibody testing of human breast cancer tissue
Availability Discontinued
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P00709
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This alpha Lactalbumin antibody is available for research use only.
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Description

Alpha-Lactalbumin is a protein that in humans is encoded by the LALBA gene. Alpha-Lactalbumin is an important whey protein in cows milk (1 g/l), and is also present in the milk of many other mammalian species. In primates, expression is upregulated in response to the hormone prolactin and increases the production of lactose. Alpha-Lactalbumin forms the regulatory subunit of the lactose synthase(LS) heterodimer and beta-1, 4-galactosyltransferase(beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transferring galactose moieties to glucose. As a multimer, alpha-Lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant that may form in acidic environments such as the stomach, called HAMLET, probably induces apoptosis in tumor and immature cells.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the alpha Lactalbumin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the N-terminus of human LALBA (KQFTKCELSQLLKDIDGY) was used as the immunogen for this alpha Lactalbumin antibody.

Storage

After reconstitution, the alpha Lactalbumin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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