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Home >> Antibodies >> Alpha B Crystallin Antibody / CRYAB

Alpha B Crystallin Antibody / CRYAB [clone ABHC-3] (RQ4994)

  Catalog No Formulation Size Price (USD)  
Image RQ4994 Antibody in PBS with 0.02% sodium azide and 50% glycerol 100 ug 359
Western blot testing of human fetal heart lysate with Alpha B Crystallin antibody. Predicted molecular weight ~20 kDa.
Availability 1-2 weeks
Species Reactivity Human
Format Purified
Clonality Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name ABHC-3
Purity Affinity purified
UniProt P02511
Applications Western blot : 1:500-1:2000
Limitations This Alpha B Crystallin antibody is available for research use only.
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Description

Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [RefSeq]

Application Notes

Optimal dilution of the Alpha B Crystallin antibody should be determined by the researcher.

Immunogen

A synthetic peptide specific to human CRYAB / Alpha B Crystallin was used as the immunogen for the Alpha B Crystallin antibody.

Storage

Store the Alpha B Crystallin antibody at -20oC.

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