- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Alpha Actinin 4 Antibody / ACTN4 [clone 93] (V8177)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8177-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
|
|
V8177-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
|
|
V8177SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG |
| Clone Name | 93 |
| Purity | Protein G affinity chromatography |
| UniProt | O43707 |
| Localization | Nuclear, cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Alpha Actinin 4 antibody is available for research use only. |
|
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Alpha Actinin 4 antibody detects alpha actinin 4, a cytoskeletal protein encoded by the ACTN4 gene. Alpha actinin 4 belongs to the spectrin family of actin-binding proteins and functions as a crosslinker of actin filaments. It contributes to cellular architecture, motility, and adhesion, while also participating in transcriptional regulation and signaling. Because mutations and dysregulation of ACTN4 are linked to cancer progression and kidney disease, Alpha Actinin 4 antibody is widely used in cytoskeletal biology, oncology, and nephrology research.
Alpha actinin 4 is expressed in many tissues but is particularly enriched in podocytes, smooth muscle, and epithelial cells. Structurally, it is a homodimer with an actin-binding domain at the N-terminus, spectrin repeats in the central region, and calmodulin-like EF-hand domains at the C-terminus. This modular structure allows alpha actinin 4 to link actin filaments to integrins and other membrane proteins, supporting focal adhesion dynamics and mechanotransduction. In addition to structural roles, it shuttles to the nucleus, where it can influence gene expression.
The Alpha Actinin 4 antibody clone 93 provides consistent and specific detection of ACTN4. Clone 93 has been referenced in peer-reviewed studies exploring podocyte injury, invasive cancer cell behavior, and actin cytoskeletal regulation. Its reliable performance supports applications in immunohistochemistry, immunoblotting, and cell biology experiments where actin network dynamics are central.
Research using clone 93 has highlighted how mutations in ACTN4 cause autosomal dominant focal segmental glomerulosclerosis, a kidney disorder characterized by proteinuria and podocyte dysfunction. In oncology, alpha actinin 4 overexpression enhances motility and invasion, correlating with poor prognosis in several cancers. Studies employing this antibody have clarified how ACTN4 integrates cytoskeletal remodeling with transcriptional programs that promote metastasis.
NSJ Bioreagents provides this Alpha Actinin 4 antibody to support research in cytoskeletal biology, oncology, and nephrology. Alternate names include ACTN4 antibody, actinin alpha 4 antibody, non-muscle alpha actinin antibody, focal adhesion actin-binding protein antibody, and podocyte cytoskeleton regulator antibody.
Optimal dilution of the Alpha Actinin 4 antibody should be determined by the researcher.
A recombinant full-length human ACTN4 protein was used as the immunogen for this Alpha Actinin 4 antibody.
Store the Alpha Actinin 4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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