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Home >> Antibodies >> Alpha Actinin 4 Antibody / ACTN4

Alpha Actinin 4 Antibody / ACTN4 [clone 93] (V8177)

  Catalog No Formulation Size Price (USD)  
Image V8177-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 499
V8177-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 219
V8177SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 499
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SDS-PAGE analysis of purified, BSA-free Alpha Actinin 4 antibody (clone 93) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG
Clone Name 93
Purity Protein G affinity chromatography
UniProt O43707
Localization Nuclear, cytoplasmic
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This Alpha Actinin 4 antibody is available for research use only.
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The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and -actinins. There are four tissue-specific -actinins, namely -actinin-1, -actinin-2, -actinin-3 and -actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each -actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding -actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.

Application Notes

Optimal dilution of the Alpha Actinin 4 antibody should be determined by the researcher.


A recombinant full-length human ACTN4 protein was used as the immunogen for this Alpha Actinin 4 antibody.


Store the Alpha Actinin 4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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