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Home >> Antibodies >> Alpha-2-Macroglobulin Antibody / A2M

Alpha-2-Macroglobulin Antibody / A2M [clone A2M/3621] (V8506)

  Catalog No Formulation Size Price (USD)  
Image V8506-100UG 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 429
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V8506-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 199
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V8506SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 429
IHC staining of FFPE human liver with Alpha-2-Macroglobulin antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human liver with Alpha-2-Macroglobulin antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free Alpha-2-Macroglobulin antibody as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2c, kappa
Clone Name A2M/3621
Purity Protein G affinity chromatography
UniProt P01023
Localization Secreted
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations This Alpha-2-Macroglobulin antibody is available for research use only.
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Description

Alpha-2-Macroglobulin (A2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, it was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on A2M. This interaction induces a conformational change, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, A2M has been shown to function as a carrier protein and regulator of cytokines during inflammation.

Application Notes

Optimal dilution of the Alpha-2-Macroglobulin antibody should be determined by the researcher.

Immunogen

A portion of amino acids 604-748 from the human protein was used as the immunogen for the Alpha-2-Macroglobulin antibody.

Storage

Store the Alpha-2-Macroglobulin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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