- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Alpha 1 Microglobulin Antibody Mouse Monoclonal AMBP/4536 / AMBP / Bikunin [clone AMBP/4536] (V5301)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5301-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5301-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5301SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2, kappa |
| Clone Name | AMBP/4536 |
| Purity | Protein A/G affinity |
| UniProt | P02760 |
| Localization | Secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Alpha 1 Microglobulin antibody is available for research use only. |
|
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Alpha 1 Microglobulin is a secreted glycoprotein encoded by the AMBP gene and widely known as Alpha-1-microglobulin. Alpha 1 Microglobulin Antibody Mouse Monoclonal AMBP/4536 recognizes this small plasma and extracellular protein, which is produced primarily in the liver and released into the bloodstream where it participates in oxidative stress regulation and heme binding. The AMBP gene, located on chromosome 9q32, encodes the precursor protein Alpha-1-microglobulin/bikunin precursor (AMBP), which is subsequently processed into the mature proteins Alpha-1-microglobulin and bikunin through proteolytic cleavage.
Alpha 1 Microglobulin antibody, also referred to as AMBP antibody and Alpha-1-microglobulin antibody in the literature, detects a protein that functions as a scavenger of free radicals and heme-derived oxidative molecules. The mature Alpha-1-microglobulin protein is secreted into plasma and extracellular fluids where it binds free heme groups and other oxidized compounds, helping protect tissues from oxidative damage. This antioxidant activity has been implicated in maintaining cellular homeostasis and protecting tissues exposed to oxidative stress.
Alpha-1-microglobulin is filtered by the glomerulus in the kidney and subsequently reabsorbed by proximal tubular epithelial cells. Because of this physiological pathway, Alpha-1-microglobulin is often studied in renal biology and kidney injury research. Increased levels of urinary Alpha-1-microglobulin can reflect tubular dysfunction or impaired protein reabsorption, making the protein a useful marker in studies examining kidney disease and tubular injury mechanisms.
In tissue-based analyses, AMBP-derived proteins are detected in liver hepatocytes where the precursor protein is synthesized, as well as in kidney tubular epithelial cells involved in protein reabsorption. Cytoplasmic staining patterns are consistent with intracellular processing and handling of the secreted protein. In addition to kidney and liver expression, Alpha-1-microglobulin has been detected in several other tissues depending on physiological conditions and circulating protein uptake.
Alpha 1 Microglobulin Antibody Mouse Monoclonal AMBP/4536 supports research applications focused on detecting Alpha-1-microglobulin expression in tissues and biological samples. Cytoplasmic staining patterns correspond with the known synthesis and intracellular handling of AMBP-derived proteins, enabling studies of oxidative stress biology, kidney tubular function, and liver-derived plasma protein production.
Optimal dilution of the Alpha 1 Microglobulin antibody mouse monoclonal AMBP/4536 should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 200-353) from the human protein was used as the immunogen for the Alpha 1 Microglobulin antibody.
Aliquot the Alpha 1 Microglobulin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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