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Home >> Antibodies >> Alpha-1-Antitrypsin Antibody / AAT / SERPINA1

Alpha-1-Antitrypsin Antibody / AAT / SERPINA1 [clone AAT/4609] (V4364)

  Catalog No Formulation Size Price (USD)  
Image V4364-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4364-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4364SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated
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Analysis of a HuProt(TM) microarray containing more than 19,000 full-length human proteins using Alpha-1-Antitrypsin antibody (clone AAT/4609). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a mAb to its intended target. A mAb is considered to specific to its intended target, if the mAb has an S-score of at least 2.5. For example, if a mAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that mAb to protein X is equal to 29.
IHC staining of FFPE human kidney carcinoma tissue with Alpha-1-Antitrypsin antibody (clone AAT/4609). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG
Clone Name AAT/4609
Purity Protein A/G affinity
UniProt P01009
Localization Cytoplasm
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations This Alpha-1-Antitrypsin antibody is available for research use only.
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Description

It recognizes a protein of 54kDa, which is identified antitrypsin (AAT). The immunohistochemical staining of AAT is useful in identification of benign and malignant hepatic tumors and yolk sac carcinomas. Positive staining for AAT is also used in detection of benign and malignant lesions of histiocytic nature. This antibody is may also useful tool in the screening of patients with cryptogenic cirrhosis or other forms of liver disease with fibrosis of uncertain origin.

Application Notes

Optimal dilution of the Alpha-1-Antitrypsin antibody should be determined by the researcher.

Immunogen

A recombinant human Alpha-1-Antitrypsin (AAT) protein fragment was used as the immunogen for the Alpha-1-Antitrypsin antibody.

Storage

Aliquot the Alpha-1-Antitrypsin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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