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Home >> Antibodies >> ALK2 Antibody / ACVR1

ALK2 Antibody / ACVR1 (F54223)

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  Catalog No Formulation Size Price (USD)  
Image F54223-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F54223-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot testing of 1) human A549, 2) human HepG2 and 3) rat testis lysate with ALK2 antibody at 1:1000. Predicted molecular weight ~57 kDa.
Western blot testing of 1) human A549, 2) human HepG2 and 3) rat testis lysate with ALK2 antibody at 1:1000. Predicted molecular weight ~57 kDa.
Availability 1-3 business days
Species Reactivity Human, Rat
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt Q04771
Applications Western blot : 1:500-1:1000
Limitations This ALK2 antibody is available for research use only.
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Description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 (activin A type I receptor) signals a particular transcriptional response in concert with activin type II receptors.

Application Notes

Titration of the ALK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 6-34 from the human protein was used as the immunogen for this ALK2 antibody.

Storage

Aliquot the ALK2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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