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Home >> Antibodies >> ALDH2 Antibody / Aldehyde dehydrogenase 2

ALDH2 Antibody / Aldehyde dehydrogenase 2 [clone AFOI-1] (RQ5101)

  Catalog No Formulation Size Price (USD)  
Image RQ5101 Antibody in PBS with 0.02% sodium azide and 50% glycerol 100 ug 359
Western blot testing of human HepG2 cell lysate with ALDH2 antibody. Predicted molecular weight ~56 kDa.
Availability 1-2 weeks
Species Reactivity Human
Format Purified
Clonality Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name AFOI-1
Purity Affinity purified
UniProt P05091
Applications Western blot : 1:500-1:2000
Limitations This ALDH2 antibody is available for research use only.
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Description

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [RefSeq]

Application Notes

Optimal dilution of the ALDH2 antibody should be determined by the researcher.

Immunogen

A synthetic peptide specific to human ALDH2 was used as the immunogen for the ALDH2 antibody.

Storage

Store the ALDH2 antibody at -20oC.

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