- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ALDH1A1 Antibody / Gastric and Hepatic Detoxification Marker [clone ALDH1A1/1381] (V7764)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V7764-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V7764-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V7764SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Rat |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | ALDH1A1/1381 |
| Purity | Protein G affinity chromatography |
| UniProt | P00352 |
| Localization | Cytoplasmic |
| Applications | Western Blot : 2-4ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This ALDH1A1 Antibody / Gastric and Hepatic Detoxification Marker is available for research use only. |
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Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is a cytoplasmic aldehyde-metabolizing enzyme involved in retinoic acid biosynthesis, oxidative stress protection, and cellular detoxification pathways. ALDH1A1 Antibody / Gastric and Hepatic Detoxification Marker (clone ALDH1A1/1381) is designed for the detection of ALDH1A1 expression in epithelial and metabolically active tissues including stomach and liver. ALDH1A1 is highly expressed in hepatocytes and gastrointestinal epithelial cells where it contributes to protection against reactive aldehydes generated during normal metabolism and inflammatory stress.
ALDH1A1 antibody, also referred to as Aldehyde dehydrogenase 1 antibody or Retinal dehydrogenase 1 antibody in the literature, recognizes a member of the aldehyde dehydrogenase superfamily that catalyzes conversion of retinaldehyde to retinoic acid. This metabolic pathway influences cellular differentiation, epithelial maintenance, and transcriptional signaling mediated through retinoid-responsive nuclear receptors. ALDH1A1 localizes predominantly to the cytoplasm and is especially abundant in tissues involved in detoxification and intermediary metabolism.
Clone ALDH1A1/1381 antibody is particularly useful for evaluating epithelial and hepatic ALDH1A1 expression patterns by western blot and immunohistochemistry. Western blot analysis demonstrates a prominent band near the expected molecular weight in human and rat stomach tissue lysates, consistent with the known gastrointestinal distribution of ALDH1A1. Strong hepatic expression is likewise consistent with the enzyme's established role in aldehyde metabolism, xenobiotic detoxification, and oxidative stress defense within hepatocytes.
ALDH1A1 has also attracted significant interest as a marker associated with stem-like cellular populations in cancer biology. Increased expression has been linked to tumor progression, chemoresistance, and cancer stem cell phenotypes in multiple carcinomas. In tissue-based studies, ALDH1A1 staining patterns may help characterize epithelial differentiation states and metabolically active tumor compartments. Because of these features, ALDH1A1 remains an important target in oncology, toxicology, and regenerative medicine research.
This mouse monoclonal ALDH1A1 antibody clone ALDH1A1/1381 supports research applications involving gastric biology, liver metabolism, epithelial differentiation, and aldehyde detoxification pathways. Human and rat tissue reactivity makes the antibody suitable for comparative gastrointestinal and hepatic expression studies in translational research settings.
For broader multi-application ALDH1A1 detection including IF and flow cytometry workflows, see our ALDH1A1 Antibody / Cancer Stem Cell and Retinoic Acid Metabolism Marker page.
Optimal dilution of the ALDH1A1 Antibody / Gastric and Hepatic Detoxification Marker should be determined by the researcher.
A human recombinant partial ALDH1A1 protein (AA 315-434) was used as the immunogen for this ALDH1 antibody.
Store the ALDH1A1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
ALDH1A1 monoclonal antibody, Aldehyde dehydrogenase 1 antibody, Retinal dehydrogenase 1 antibody, ALDH1A1 IHC antibody, Hepatic detoxification marker antibody
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![ALDH1A1 Antibody Human Mouse Rat Testis WB. Western blot testing of human [A] and mouse [B] liver, and rat [C] testis lysate with ALDH1A1 antibody at 0.3ug/ml. Predicted molecular weight ~55 kDa.](https://www.nsjbio.com/plp/thumb_image/img-R34035-100UG-1.jpg?v=1784765065 "ALDH1A1 Antibody Human Mouse Rat Testis WB. Western blot testing of human [A] and mouse [B] liver, and rat [C] testis lysate with ALDH1A1 antibody at 0.3ug/ml. Predicted molecular weight ~55 kDa.")
