- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
AKT1/2/3 Antibody [clone 31A24] (FY12694)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12694 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 439 |
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AKT1/2/3 antibody detects the three isoforms of AKT, also known as protein kinase B, encoded by the AKT1, AKT2, and AKT3 genes. These serine threonine kinases are central regulators of cell survival, growth, metabolism, and angiogenesis. AKT proteins are activated downstream of phosphoinositide 3 kinase signaling in response to growth factors and insulin. Each isoform has overlapping and unique functions, ensuring precise control of cellular physiology.
AKT1/2/3 antibody is widely applied in cancer biology, metabolism research, and neuroscience. AKT1 regulates cell survival and growth, AKT2 controls glucose metabolism, and AKT3 influences brain development and function. Dysregulation of AKT signaling is a hallmark of many cancers, diabetes, and neurological diseases. By detecting all three isoforms, researchers can evaluate global AKT activity and isoform specific contributions.
The antibody is validated for western blotting, immunohistochemistry, immunofluorescence, and ELISA. Western blot assays detect AKT isoforms in diverse tissues, immunohistochemistry maps AKT distribution in tumors and metabolic organs, and immunofluorescence reveals cytoplasmic and membrane localization upon activation. ELISA provides quantitative measurement of AKT levels in clinical and experimental samples. These applications make AKT1/2/3 antibody a versatile reagent for broad pathway analysis.
AKT kinases regulate multiple downstream targets including mTOR, FOXO transcription factors, and GSK3. They promote protein synthesis, inhibit apoptosis, and modulate metabolism. Aberrant AKT signaling drives oncogenesis, drug resistance, and metabolic disorders. By applying AKT1/2/3 antibody, scientists can investigate how PI3K AKT pathways integrate signals from growth factors, nutrients, and stress.
Therapeutically, AKT inhibitors are under development for cancer and metabolic disease. Measuring AKT expression with antibody based assays provides biomarkers for drug development and patient stratification. AKT1/2/3 antibody therefore supports translational research linking kinase biology to clinical intervention.
AKT1/2/3 antibody from NSJ Bioreagents provides dependable specificity for detecting all three isoforms of protein kinase B. Its reliable performance across multiple assays supports research into survival, metabolism, and oncogenic signaling.
Optimal dilution of the AKT1/2/3 antibody should be determined by the researcher.
A synthesized peptide derived from human AKT1 + AKT2 + AKT3 was used as the immunogen for the AKT1/2/3 antibody.
Store the AKT1/2/3 antibody at -20oC.
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