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Home >> Antibodies >> AKR1C1/2 Antibody

AKR1C1/2 Antibody (R32504)

  Catalog No Formulation Size Price (USD)  
Image R32504 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of 1) rat liver and 2) human HeLa lysate with AKR1C1/2 antibody at 0.5ug/ml. Predicted molecular weight ~37 kDa (AKR1C1) and ~37 kDa (AKR1C2).
Availability 1-3 business days
Species Reactivity Human, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt Q04828 , P52895
Localization Cytoplasmic
Applications Western blot : 0.5-1ug/ml
Limitations This AKR1C1/2 antibody is available for research use only.
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Description

AKR1C1 and AKR1C2 are members of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. AKR1C1 binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. The AKR1C1 gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.

Application Notes

Differences in protocols and secondary/substrate sensitivity may require the AKR1C1/2 antibody to be titrated for optimal performance.

Immunogen

Amino acids M1-K123 from human AKR1C1 were used as the immunogen for the AKR1C1/2 antibody.

Storage

After reconstitution, the AKR1C1/2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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