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Home >> Antibodies >> AIRE Antibody

AIRE Antibody (R32465)

  Catalog No Formulation Size Price (USD)  
Image R32465 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of 1) rat testis and 2) human HeLa lysate with AIRE antibody at 0.5ug/ml. Expected molecular weight ~58 kDa.
Flow cytometry testing of human THP1 cells with AIRE antibody at 1ug/10^6 cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= AIRE antibody.
Flow cytometry testing of human HL60 cells with AIRE antibody at 1ug/10^6 cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= AIRE antibody.
Availability 1-3 business days
Species Reactivity Human, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt O43918
Applications Western blot : 0.5-1ug/ml
Flow Cytometry : 1-3ug/10^6 cells
Limitations This AIRE antibody is available for research use only.
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Description

The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

Application Notes

Optimal dilution of the AIRE antibody should be determined by the researcher.

Immunogen

Amino acids M1-K120 from the human protein were used as the immunogen for the AIRE antibody.

Storage

Prior to reconstitution, store at 4oC. After reconstitution, the AIRE antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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