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Home >> Antibodies >> AIRE Antibody

AIRE Antibody (R32465)

  Catalog No Formulation Size Price (USD)  
Image R32465 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 389
IHC staining of FFPE human tonsil tissue with AIRE antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
Western blot testing of 1) human RT4, 2) human HeLa, 3) rat testis and 4) mouse thymus lysate with AIRE antibody at 0.5ug/ml. Expected molecular weight ~58 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt O43918
Applications Western blot : 0.5-1ug/ml
Immunohistochemistry : 2-5ug/ml
Limitations This AIRE antibody is available for research use only.
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Description

The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

Application Notes

Optimal dilution of the AIRE antibody should be determined by the researcher.

Immunogen

Amino acids M1-K120 from the human protein were used as the immunogen for the AIRE antibody.

Storage

Prior to reconstitution, store at 4oC. After reconstitution, the AIRE antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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