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'Apoptosis-inducing factor 1, mitochondrial' functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity.
Optimal dilution of the AIFM1 antibody should be determined by the researcher.
A synthetic peptide specific to human AIF / AIFM1 was used as the immunogen for the AIFM1 antibody.
Store the AIFM1 antibody at -20oC.
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