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Home >> Antibodies >> AHR Antibody (Aryl hydrocarbon Receptor)

AHR Antibody (Aryl hydrocarbon Receptor) (R30877)

  Catalog No Formulation Size Price (USD)  
Image R30877 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of AHR antibody and mouse samples: 1. brain; 2. heart; 3. liver tissue lysate. Predicted molecular weight ~ 95kDa.
IHC-P: AHR antibody testing of mouse heart tissue
IHC-P: AHR antibody testing of mouse brain tissue
Availability 1-3 business days
Species Reactivity Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P30561
Applications Western blot : 0.5-1ug/ml
Immunohistochemistry (FFPE) : 0.5-1ug/ml
Limitations This AHR antibody is available for research use only.
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Description

Aryl hydrocarbon receptor is a member of the family of basic helix-loop-helix transcription factors. It is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones. Estrogenic actions of AHR agonists were detected in wildtype ovariectomized mouse uteri, but were absent in Ahr -/- or Er-alpha -/- ovariectomized mice. Complex assembly and ubiquitin ligase activity of CUL4B/AHR in vitro and in vivo are dependent on the AHR ligand. In the CUL4B/AHR complex, ligand-activated AHR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the AHR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of mouse Aryl hydrocarbon Receptor (EAALKHEQIGHAQDV) was used as the immunogen for this AHR antibody.

Storage

After reconstitution, the AHR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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