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Home >> Antibodies >> Adenosine deaminase Antibody / ADA1

Adenosine deaminase Antibody / ADA1 (R32414)

  Catalog No Formulation Size Price (USD)  
Image R32414 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of human 1) HeLa and 2) COLO320 cell lysate with Adenosine deaminase antibody. Expected/observed molecular weight ~41 kDa.
IHC testing of FFPE human tonsil with Adenosine deaminase antibody. HIER: Boil the paraffin sections in pH 6, 10mM citrate buffer for 20 minutes and allow to cool prior to testing.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt P00813
Localization Cytoplasmic, cell membrane
Applications Western blot : 0.1-0.5ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This Adenosine deaminase antibody is available for research use only.
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Description

Adenosine deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme involved in purine metabolism. Primarily, ADA in humans is involved in the development and maintenance of the immune system. However, ADA association has also been observed with epithelial cell differentiation, neurotransmission, and gestation maintenance. It has also been proposed that ADA, in addition to adenosine breakdown, stimulates release of excitatory amino acids and is necessary to the coupling of A1 adenosine receptors and heterotrimeric G proteins. Adenosine deaminase deficiency leads to pulmonary fibrosis, suggesting that chronic exposure to high levels of adenosine can exacerbate inflammation responses rather than suppressing them. It has also been recognized that adenosine deaminase protein and activity is upregulated in mouse hearts that overexpress HIF-1 alpha, which in part explains the attenuated levels of adenosine in HIF-1 alpha expressing hearts during ischemic stress.

Application Notes

Optimal dilution of the Adenosine deaminase antibody should be determined by the researcher.

Immunogen

Amino acids Q135-L363 of the human protein were used as the immunogen for the Adenosine deaminase antibody.

Storage

After reconstitution, the Adenosine deaminase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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