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Home >> Antibodies >> ADAMTS5 Antibody (C-Terminal region) [Discontinued]

ADAMTS5 Antibody (C-Terminal region) [Discontinued] (R31183)

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Image R31183 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 285
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Western blot testing of ADAMTS5 antibody; Lane 1: rat liver and human samples 2: HeLa; 3: COLO320; 4: MCF-7; 5: A549; 6: SGC cell lysate. Predicted molecular weight ~102 kDa (unmodified, larger if glycosylated), ~73 kDa (cleaved).
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Western blot testing of ADAMTS5 antibody; Lane 1: rat liver and human samples 2: HeLa; 3: COLO320; 4: MCF-7; 5: A549; 6: SGC cell lysate. Predicted molecular weight ~102 kDa (unmodified, larger if glycosylated), ~73 kDa (cleaved).
Western blot testing of ADAMTS5 antibody; Lane 1: rat heart and human samples 2: HeLa; 3: COLO320; 4: MCF-7; 5: A549 cell lysate. Predicted molecular weight ~102 kDa (unmodified, larger if glycosylated), ~73 kDa (cleaved).
IHC-P: ADAMTS5 antibody testing of rat brain tissue
Availability Discontinued
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt Q9UNA0
Localization Cytoplasmic
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This ADAMTS5 antibody is available for research use only.
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Description

A Disintegrin-Like and Metalloproteinase with Thrombospondin Type 1 Motif, 5, is an enzyme that in humans is encoded by the ADAMTS5 gene. It is a member of the large ADAMTS family of zinc-dependent proteases. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. By somatic cell hybrid analysis, Hurskainen et al.(1999) mapped the human ADAMTS5 gene to chromosome 21. Using mouse models, Echtermeyer et al.(2009) showed that Sdc4 controls a pathway that activates Adamts5 at the chondrocyte cell surface through Erk1/Erk2 activation of Mmp3.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the ADAMTS5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Amino acid 772-787 (TAYLALKKKNGEYLIN) from the C-terminal portion of human ADAMTS5 were used as the immunogen for this ADAMTS5 antibody.

Storage

After reconstitution, the ADAMTS5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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