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A Disintegrin-Like and Metalloproteinase with Thrombospondin Type 1 Motif, 5, is an enzyme that in humans is encoded by the ADAMTS5 gene. It is a member of the large ADAMTS family of zinc-dependent proteases. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. By somatic cell hybrid analysis, Hurskainen et al.(1999) mapped the human ADAMTS5 gene to chromosome 21. Using mouse models, Echtermeyer et al.(2009) showed that Sdc4 controls a pathway that activates Adamts5 at the chondrocyte cell surface through Erk1/Erk2 activation of Mmp3.
The stated application concentrations are suggested starting amounts. Titration of the ADAMTS5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Amino acid 772-787 (TAYLALKKKNGEYLIN) from the C-terminal portion of human ADAMTS5 were used as the immunogen for this ADAMTS5 antibody.
After reconstitution, the ADAMTS5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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