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Home >> Antibodies >> ADAM17 Antibody

ADAM17 Antibody (R30942)

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  Catalog No Formulation Size Price (USD)  
Image R30942 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of ADAM17 antibody and Lane 1: human placenta; 2: HeLa; 3: PANC; 4: 293T cell lysate. Expected molecular weight: 80-130KD depending on level of glycosylation
Western blot testing of ADAM17 antibody and Lane 1: human placenta; 2: HeLa; 3: PANC; 4: 293T cell lysate. Expected molecular weight: 80-130KD depending on level of glycosylation
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P78536
Applications Western blot : 0.5-1ug/ml
Limitations This ADAM17 antibody is available for research use only.
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Description

ADAM metallopeptidase domain 17, also called TACE (Tumor necrosis factor-alpha-converting enzyme), is an enzyme that belongs to the ADAM proteinfamily of disintegrins and metalloproteases. Expression studies showed that the encoded protein cleaves precursor tumor necrosis factor-alpha to its mature form. Northern blot analysis revealed that the gene was expressed as a 5-kb mRNA in all tissues examined. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-alpha) at the surface of the cell, and from within theintracellular membranesof the trans-Golgi network. This process, which is also known as shedding, involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-alpha), and is of known physiological importance. ADAM17 was the first sheddase to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the ADAM17 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of human ADAM17 (AASFKLQRQNRVDSKETEC) was used as the immunogen for this ADAM17 antibody.

Storage

After reconstitution, the ADAM17 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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