- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ACVR2A Antibody / Activin receptor type-2A (FY13357)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13357 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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ACVR2A antibody detects Activin receptor type-2A, a transmembrane serine/threonine kinase receptor encoded by the ACVR2A gene on chromosome 2q22.2. ACVR2A is a member of the transforming growth factor beta receptor family and functions as a type II receptor for activins, inhibins, and related growth factors. It is broadly expressed in reproductive organs, liver, skeletal muscle, and nervous tissue, mediating diverse biological processes including cell growth, differentiation, and embryonic patterning. ACVR2A serves as a central component in activin-mediated signaling that controls reproduction, metabolism, and tissue repair.
ACVR2A binds activin A, activin B, and growth differentiation factors such as GDF8 (myostatin) and GDF11, initiating phosphorylation of type I receptor partners (ALK4/ALK7). This triggers SMAD2 and SMAD3 activation and downstream transcriptional responses that regulate gene expression in target tissues. Co-localization studies show ACVR2A clustering with ALK4 at the plasma membrane and endosomal compartments, where ligand-induced receptor internalization fine-tunes signaling output.
Structurally, ACVR2A features an extracellular ligand-binding domain, a single transmembrane region, and an intracellular kinase domain responsible for catalytic activity. It belongs to the transforming growth factor beta receptor family of serine/threonine kinases, sharing sequence homology with ACVR2B. The receptor interacts with ligands and type I receptors to form heterotetrameric complexes required for signal propagation. Known ligands include activins, inhibins, GDF8, and GDF11, which influence muscle growth, reproductive physiology, and developmental patterning.
Functionally, ACVR2A mediates activin signaling involved in follicle-stimulating hormone regulation, gonadal development, and muscle differentiation. It also participates in metabolic control, modulating insulin sensitivity and energy expenditure. During embryogenesis, ACVR2A expression is essential for mesoderm formation, neural tube development, and left-right axis determination. In adult tissues, ACVR2A supports tissue regeneration and wound repair by activating SMAD-dependent transcriptional networks.
Dysregulation of ACVR2A signaling contributes to reproductive disorders, cancer, and muscle-wasting diseases. Loss-of-function mutations can impair fertility, while overactivation has been linked to tumor progression through transforming growth factor beta pathway cross-talk. In hepatocellular carcinoma, reduced ACVR2A expression correlates with increased proliferation and metastasis. Pathway associations include transforming growth factor beta, SMAD, and MAPK signaling networks, which coordinate growth and differentiation across cell types. Isoform-specific studies reveal that ACVR2A and its paralog ACVR2B exhibit distinct ligand affinities and tissue distributions, allowing fine-tuned activin signaling.
Immunohistochemical staining using ACVR2A antibody shows membrane and cytoplasmic localization in reproductive, hepatic, and neural tissues. The ACVR2A antibody from NSJ Bioreagents is an excellent reagent for exploring transforming growth factor beta and activin receptor signaling, development, and disease pathogenesis.
Optimal dilution of the ACVR2A antibody should be determined by the researcher.
E.coli-derived human ACVR2A recombinant protein (Position: A20-N138) was used as the immunogen for the ACVR2A antibody.
After reconstitution, the ACVR2A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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