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- Email: info@nsjbio.com
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Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 (activin A type I receptor) signals a particular transcriptional response in concert with activin type II receptors.
Titration of the ACVR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 85-123 from the human protein was used as the immunogen for this ACVR1 antibody.
Aliquot the ACVR1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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