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Home >> Antibodies >> Activin A Receptor Type IB Antibody

Activin A Receptor Type IB Antibody (F54951)

  Catalog No Formulation Size Price (USD)  
Image F54951-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 359
Image
F54951-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 149
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity purified
UniProt P36896
Applications Western blot : 1:500-1:2000
Flow cytometry : 1:25 (1x10e6 cells)
Limitations This Activin A Receptor Type IB antibody is available for research use only.
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Description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The gene for ACVR1B (activin A type IB receptor) is composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.

Application Notes

The stated application concentrations are suggested starting points. Titration of the Activin A Receptor Type IB antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 39-68 from the human protein was used as the immunogen for the Activin A Receptor Type IB antibody.

Storage

Aliquot the Activin A Receptor Type IB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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