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- Email: info@nsjbio.com
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Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.
Optimal dilution of the Actinin Alpha 2 antibody should be determined by the researcher.
Amino acids 557-692 from the human protein were used as the immunogen for this ACTN2 antibody.
Store the Actinin Alpha 2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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