- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ACP3 Antibody / Prostatic acid phosphatase / PAP / ACPP (RQ6919)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ6919 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P15309 |
| Localization | Cytoplasmic |
| Applications | Western Blot : 0.5-1 ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Immunofluorescence : 5ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This ACP3 antibody is available for research use only. |
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ACP3 antibody targets Prostatic acid phosphatase (ACP3), also known as PAP or ACPP, a secreted and intracellular acid phosphatase that catalyzes the hydrolysis of phosphate esters under acidic conditions. ACP3 is best known for its high expression in prostate epithelial cells, where it contributes to phosphate metabolism and cellular signaling within the prostate microenvironment. The protein localizes to secretory vesicles and the cytoplasm, with extracellular presence following secretion, reflecting its multifunctional roles in both intracellular and extracellular contexts.
Functionally, ACP3 participates in dephosphorylation reactions that influence nucleotide metabolism, signal transduction, and cellular communication. Beyond the prostate, ACP3 expression has been reported in additional tissues and cell types, including subsets of neurons and immune-related cells, suggesting broader biological roles. ACP3 activity can modulate levels of phosphorylated substrates, thereby indirectly affecting pathways involved in cell growth, differentiation, and responsiveness to environmental cues. An ACP3 antibody supports studies examining phosphatase activity and tissue-specific regulation of phosphate metabolism.
ACP3 has long been used as a biochemical and histological marker of prostate tissue and prostate-related biology. Changes in ACP3 expression or activity reflect alterations in cellular differentiation state and secretory function. While newer biomarkers are often used clinically, ACP3 remains biologically relevant for understanding prostate cell physiology and enzyme regulation. An ACP3 antibody enables analysis of ACP3 expression patterns and localization in normal and experimental systems.
From a biological and disease-relevance perspective, ACP3 has been studied in the context of prostate disorders, neuronal signaling, and immune modulation. In neural tissues, ACP3-related phosphatase activity has been implicated in pain signaling pathways and synaptic regulation, highlighting non-prostatic functions of the protein. These diverse roles underscore the importance of ACP3 as a multifunctional phosphatase with tissue-dependent activities.
At the molecular level, ACP3 is encoded by the ACPP gene and produces a protein of approximately 386 amino acids that undergoes post-translational processing associated with secretion. The enzyme contains conserved catalytic residues characteristic of acid phosphatases, enabling efficient phosphate ester hydrolysis at low pH. Regulation of ACP3 expression and activity is influenced by tissue context and cellular differentiation state. An ACP3 antibody supports research applications focused on phosphatase biology, prostate cell function, and tissue-specific enzyme regulation, with NSJ Bioreagents providing reagents intended for research use.
Optimal dilution of the ACP3 antibody should be determined by the researcher.
Recombinant human PAP/ACP3 protein (amino acids E150-D386) was used as the immunogen for the ACP3 antibody.
After reconstitution, the ACP3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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