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Home >> Antibodies >> AChR Antibody (nicotinic)

AChR Antibody (nicotinic) (R30303)

  Catalog No Formulation Size Price (USD)  
Image R30303 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of AChR antibody and rat skeletal muscle tissue lysate
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P02708
Applications Western blot : 0.5-1ug/ml
Limitations This AChR antibody is available for research use only.
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Description

AChR alpha, also called CHRNA, is mapped on 2q24-q32. This gene encodes the alpha subunit of the muscle acetylcholine receptor, which is the main target of pathogenic autoantibodies in autoimmune myasthenia gravis. The protein-coding sequence of the human alpha subunit gene is divided into 9 exons that correspond to different structural and functional domains of the precursor molecule.

Application Notes

Titration of the AChR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Amino acids 22-36 (EHETRLVAKLFKDYS) from the alpha subunit were used as the immunogen for this nicotinic AChR antibody (100% homologous in human and rat).

Storage

Store the lyophilized AChR antibody at 4oC. After reconstitution, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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