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Home >> Antibodies >> ACE2 Antibody / Angiotensin-Converting Enzyme 2

ACE2 Antibody / Angiotensin-Converting Enzyme 2 [clone ACE2/7202] (V5785)

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  Catalog No Formulation Size Price (USD)  
Image V5785-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 539
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V5785-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 249
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V5785SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 539
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IHC staining of FFPE human kidney tissue with ACE2 antibody (clone ACE2/7202). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human kidney tissue with ACE2 antibody (clone ACE2/7202). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free ACE2 antibody (clone ACE2/7202) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name ACE2/7202
Purity Protein G affinity
UniProt Q9BYF1
Localization Cell membrane, Secreted
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This ACE2 antibody is available for research use only.
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Description

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

Application Notes

Optimal dilution of the ACE2 antibody should be determined by the researcher.

Immunogen

A portion of amino acids 1-300 from human ACE2 was used as the immunogen for the ACE2 antibody.

Storage

Aliquot the ACE2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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