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Home >> Antibodies >> ACE2 Antibody / Angiotensin-Converting Enzyme 2

ACE2 Antibody / Angiotensin-Converting Enzyme 2 [clone ACE2/6788R] (V8992)

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  Catalog No Formulation Size Price (USD)  
Image V8992-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V8992-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V8992SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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IHC staining of FFPE human small intestine tissue with ACE2 antibody (clone ACE2/6788R) at 2ug/ml in PBS for 30min RT. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human small intestine tissue with ACE2 antibody (clone ACE2/6788R) at 2ug/ml in PBS for 30min RT. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free ACE2 antibody (ACE2/6788R) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name ACE2/6788R
Purity Protein A/G affinity
UniProt Q9BYF1
Localization Cell membrane, Secreted
Applications ELISA (For coating :
order BSA-free format) :
Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This ACE2 antibody is available for research use only.
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Description

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II toangiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage ofangiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

Application Notes

Optimal dilution of the ACE2 antibody should be determined by the researcher.

Immunogen

A portion of amino acids 705-805 was used as the immunogen for the ACE2 antibody.

Storage

Aliquot the ACE2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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