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Home >> Antibodies >> ACE Antibody

ACE Antibody (R31546)

  Catalog No Formulation Size Price (USD)  
Image R31546 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of ACE antibody and recombinant human protein (0.5ng)
IHC-P: ACE antibody testing of human placenta tissue
IHC-P: ACE antibody testing of mouse lung tissue
IHC-P testing of rat lung tissue
IHC-P testing of rat lung tissue
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Gene ID 1636
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
IHC (Frozen) : 0.5-1ug/ml
Limitations This ACE antibody is available for research use only.
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Description

Angiotensin-converting enzyme, an exopeptidase, is a circulating enzyme that participates in the body's renin-angiotensin system(RAS), which mediates extracellular volume (i.e. that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. It is secreted by pulmonary and renal endothelial cells and catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II. Using a DNA marker at the growth hormone gene locus, which they characterized as 'extremely polymorphic' and which showed no recombination with ACE, the gene was mapped to 17q22-q24, consistent with the in situ hybridization mapping to 17q23. ACE, or kininase II, is a dipeptidyl carboxypeptidase that plays an important role in blood pressure regulation and electrolyte balance by hydrolyzing angiotensin I into angiotensin II, a potent vasopressor, and aldosterone-stimulating peptide. The enzyme is also able to inactivate bradykinin, a potent vasodilator.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the ACE antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Human partial recombinant protein (AA 651-864) was used as the immunogen for this ACE antibody.

Storage

After reconstitution, the ACE antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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