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Home >> Antibodies >> ACE Antibody / Angiotensin-Converting Enzyme

ACE Antibody / Angiotensin-Converting Enzyme (F50773)

  Catalog No Formulation Size Price (USD)  
Image F50773-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F50773-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
Western blot analysis of ACE antibody and mouse lung tissue lysate. Expected molecular weight 140-170 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt P12821
Applications Western blot : 1:1000
Limitations This ACE antibody is available for research use only.
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Description

ACE is an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active.

Application Notes

Titration of the ACE antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 1274-1306 from the human protein was used as the immunogen for this ACE antibody.

Storage

Aliquot the ACE antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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