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Home >> Antibodies >> ACE Antibody [Angiotensin Converting Enzyme]

ACE Antibody [Angiotensin Converting Enzyme] (R31318)

  Catalog No Formulation Size Price (USD)  
Image R31318 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
IHC-P: ACE antibody testing of human prostate cancer tissue
IHC-P: ACE antibody testing of human placenta tissue
Western blot testing of ACE antibody and (1) HeLa, (2) A549 and (3) 22RV1 lysate. Expected molecular weight 140-170 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P12821
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This ACE antibody is available for research use only.
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Description

Angiotensin converting enzyme, also called DCP or CD143, is a zinc-containing dipeptidyl carboxypeptidase widely distributed in mammalian tissues and is though to play a critical role in blood pressure regulation. The ACE gene is mapped to 17q23.3. This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the ACE1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the middle region of human Angiotensin Converting Enzyme 1 (TQARKFDVNQLQNT) was used as the immunogen for this ACE antibody.

Storage

After reconstitution, the ACE antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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