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Home >> Antibodies >> ABL1 Antibody

ABL1 Antibody (F50695)

  Catalog No Formulation Size Price (USD)  
Image F50695-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F50695-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
Western blot analysis of ABL1 antibody and Y79 lysate. Predicted molecular weight ~120-150 kDa.
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
UniProt P00519
Applications Western blot : 1:1000
Limitations This ABL1 antibody is available for research use only.
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Description

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.

Application Notes

Titration of the ABL1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 231-260 from the human protein was used as the immunogen for this ABL1 antibody.

Storage

Aliquot the ABL1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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