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Home >> Antibodies >> ABCE1 Antibody

ABCE1 Antibody (R32488)

  Catalog No Formulation Size Price (USD)  
Image R32488 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of 1) rat spleen, 2) mouse thymus and 3 human HeLa lysate with ABCE1 antibody at 0.5ug/ml. Predicted molecular weight ~67 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt P61221
Localization Cytoplasmic
Applications Western blot : 0.5-1ug/ml
Limitations This ABCE1 antibody is available for research use only.
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Description

ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumorcell proliferation and antiapoptosis.

Application Notes

Differences in protocols and secondary/substrate sensitivity may require the ABCE1 antibody to be titrated for optimal performance.

Immunogen

Amino acids K419-D599 from the human protein were used as the immunogen for the ABCE1 antibody.

Storage

After reconstitution, the ABCE1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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