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Home >> Antibodies >> ABCD2 Antibody

ABCD2 Antibody (F42334)

  Catalog No Formulation Size Price (USD)  
Image F42334-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F42334-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
ABCD2 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue.
ABCD2 antibody flow cytometric analysis of K562 cells (right histogram) compared to a negative control (left histogram). FITC-conjugated donkey-anti-rabbit secondary Ab was used for the analysis.
ABCD2 antibody western blot analysis in K562 lysate. Predicted molecular weight: ~83 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q9UBJ2
Localization Cytoplasmic
Applications Western blot : 1:1000
IHC (Paraffin) : 1:10-1:50
Flow Cytometry : 1:10-1:50
Limitations This ABCD2 antibody is available for research use only.
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Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.

Application Notes

Titration of the ABCD2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 553-582 from the human protein was used as the immunogen for this ABCD2 antibody.

Storage

Aliquot the ABCD2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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