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Home >> Antibodies >> ABCC4 Antibody / MRP4

ABCC4 Antibody / MRP4 (R30966)

  Catalog No Formulation Size Price (USD)  
Image R30966 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of ABCC4 antibody and Lane 1: recombinant human protein 10ng; 2: 5ng; 3: 2.5ng
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt O15439
Applications Western blot : 0.5-1ug/ml
Limitations This ABCC4 antibody is available for research use only.
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Description

ATP-binding cassette, subfamily c, member 4, also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene. The protein belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. By radiation hybrid analysis, Kool et al.(1997) mapped the gene to chromosome 13. Using FISH, Lee et al.(1998) refined the localization to chromosome 13q32. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of ABCC4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of protein activity or knockdown via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. Van de Ven et al.(2008) concluded that the protein contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the ABCC4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the N-terminus of human ABCC4/MRP4 (WLNPLFKIGHKRRLEEDD) was used as the immunogen for this ABCC4 antibody.

Storage

After reconstitution, the ABCC4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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