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Home >> Antibodies >> ABCB11 Antibody [Discontinued, view alternatives]

ABCB11 Antibody [Discontinued, view alternatives] (R30464)

  Catalog No Formulation Size Price (USD)  
Image R30464 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 299
Western blot testing of ABCB11 antibody and Lane 1: rat liver; 2: (h) SMMC-7721; 3: (h) MB231 cell lysate
IHC-P: ABCB11 antibody testing of human liver cancer tissue
Availability Discontinued
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt O95342
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This ABCB11 antibody is available for research use only.
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Description

Bile Salt Export Pump (BSEP) is a protein which in humans is encoded by the ABCB11 gene. It is a member of the superfamily of ATP-binding cassette (ABC) transporters. It is mapped to chromosome 2q24. The ABCB11 protein is mainly expressed in the liver. Mutation of the gene is associated with progressive familial intrahepatic cholestasis type 2 (PFIC2) which causes an increases the risk of hepatocellular carcinoma in early life.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the ABCB11 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of human ABCB11 (THEELMAQKGAYYKL) was used as the immunogen for this ABCB11 antibody.

Storage

After reconstitution, the ABCB11 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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