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Home >> Antibodies >> ABCB1 Antibody / ATP-binding cassette sub-family B member 1 / P-glycoprotein / MDR1

ABCB1 Antibody / ATP-binding cassette sub-family B member 1 / P-glycoprotein / MDR1 [clone MDR1/8986R] (V5208)

  Catalog No Formulation Size Price (USD)  
Image V5208-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V5208-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V5208SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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IHC staining of FFPE human adrenal gland tissue with ABCB1 antibody (clone MDR1/8986R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name MDR1/8986R
Purity Protein A/G affinity
UniProt P08183
Localization Membrane
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This ABCB1 antibody is available for research use only.
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Description

Cells selected for resistance to a single cytotoxic drug may become crossresistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). MDR proteins (Mdrs) are members of a highly conserved superfamily of ATP-binding cassette transport proteins. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. The Mdr-1 gene is known as ABCB1 and is located on human chromosome 7q21.12. The mouse homolog of Mdr-1 is known as Mdr-3. Interestingly, a murine protein by the name of Mdr-1 exists and is encoded by the murine Abcb1b gene, but it is not homologous with human Mdr-1.

Application Notes

Optimal dilution of the ABCB1 antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 500-700) from the human protein was used as the immunogen for the ABCB1 antibody.

Storage

Aliquot the ABCB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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