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Home >> Antibodies >> ABCA3 Antibody [Discontinued, view alternatives]

ABCA3 Antibody [Discontinued, view alternatives] (R31383)

  Catalog No Formulation Size Price (USD)  
Image R31383 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 299
Western blot testing of ABCA3 antibody and Lane 1: rat brain; 2: human HeLa lysate. Expected molecular weight: 180-191 kDa.
Availability Discontinued
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt Q99758
Applications Western blot : 0.5-1ug/ml
Limitations This ABCA3 antibody is available for research use only.
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Description

ATP-binding cassette sub-family A member 3 is a protein that in humans is encoded by the ABCA3 gene. This protein is a member of the ABC1 subfamily. It is mapped to 16p13.3. ABCA3 is homologous to C. elegans protein ced7. Ced7 functions to translocate molecules that mediate homotypic adhesion between the cell surfaces of the dying and engulfing cells, and ABCA3 may be functionally similar to it. This gene is associated with Surfactant metabolism dysfunction type 3, and it plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol. Additionally, the protein is also critical for the proper formation of lamellar bodies.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the ABCA3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the N-terminus of human ATP binding cassette sub family A member 3 (FTYTALTIARAVVQEKER) was used as the immunogen for this ABCA3 antibody.

Storage

After reconstitution, the ABCA3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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