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Home >> Antibodies >> Aanat Antibody

Aanat Antibody (RQ6914)

  Catalog No Formulation Size Price (USD)  
Image RQ6914 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 419
Western blot testing of mouse eye lysate with Aanat antibody. Predicted molecular weight ~23 kDa.
Availability 1-3 business days
Species Reactivity Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt O88816
Applications Western blot : 0.5-1 ug/ml
Direct ELISA : 0.1-0.5ug/ml
Limitations This Aanat antibody is available for research use only.
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Description

Aralkylamine N-acetyltransferase (AANAT) (EC 2.3.1.87), also known as arylalkylamine N-acetyltransferase or serotonin N-acetyltransferase (SNAT), is an enzyme that is involved in the day/night rhythmic production of melatonin, by modification of serotonin. It is in humans encoded by the ~2.5 kb AANAT gene containing four exons, located on chromosome 17q25. The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants.

Application Notes

Optimal dilution of the Aanat antibody should be determined by the researcher.

Immunogen

Recombinant mouse Aanat protein (amino acids C24-C205) was used as the immunogen for the Aanat antibody.

Storage

After reconstitution, the Aanat antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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