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Home >> Antibodies >> AANAT Antibody

AANAT Antibody (F51822)

  Catalog No Formulation Size Price (USD)  
Image F51822-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F51822-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
Western blot analysis of AANAT antibody and human Y79 lysate. Predicted molecular weight ~23 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q16613
Applications Western blot : 1:1000
Limitations This AANAT antibody is available for research use only.
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Description

Serotonin N-acetyltransferase/AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.

Application Notes

Titration of the AANAT antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 27-54 from the human protein was used as the immunogen for this AANAT antibody.

Storage

Aliquot the AANAT antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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