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Home >> Antibodies >> 5HT2A Receptor Antibody

5HT2A Receptor Antibody (R30442)

  Catalog No Formulation Size Price (USD)  
Image R30442 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of 5HT2A Receptor antibody and Lane 1: rat brain; 2: rat brain; 3: mouse brain; 4: mouse brain and human samples 5: U87; 6: SMMC-7721; 7: HT1080; 8: COLO320. Predicted/observed molecular weight ~53kDa.
IHC-P: 5HT2A Receptor antibody testing of rat brain tissue
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P28223
Localization Cytoplasmic, membrane
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This 5HT2A Receptor antibody is available for research use only.
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Description

The mammalian HTR2A (5-HT2A receptor) is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). This is the main excitatory receptor subtype among the GPCRs for serotonin(5-HT), although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbit frontal cortex. This receptor was given importance first as the target of psychedelic drugs like LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones.5-HT2A also happens to be a necessary receptor for the spread of the human polyoma virus called JC virus. Sparkes et al.(1991) concluded that the gene is located on 13q14-q21 in man and on chromosome 14 in the mouse.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the 5HT2A Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of human 5HT2A Receptor (AYKSSQLQMGQKKNS) was used as the immunogen for this 5HT2A Receptor antibody.

Storage

After reconstitution, the 5HT2A Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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