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Home >> Antibodies >> 5-Lipoxygenase Antibody / ALOX5

5-Lipoxygenase Antibody / ALOX5 [clone AECE-1] (RQ5292)

  Catalog No Formulation Size Price (USD)  
Image RQ5292 Antibody in PBS with 0.02% sodium azide and 50% glycerol 100 ug 359
Western blot testing of human K562 cell lysate with 5-Lipoxygenase antibody. Predicted molecular weight ~78 kDa.
Availability 1-2 weeks
Species Reactivity Human
Format Purified
Clonality Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name AECE-1
Purity Affinity purified
UniProt P09917
Applications Western blot : 1:500-1:2000
Limitations This 5-Lipoxygenase antibody is available for research use only.
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Description

The ALOX5 gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. [RefSeq]

Application Notes

Optimal dilution of the 5-Lipoxygenase antibody should be determined by the researcher.

Immunogen

A synthetic peptide specific to human 5-Lipoxygenase / ALOX5 was used as the immunogen for the 5-Lipoxygenase antibody.

Storage

Store the 5-Lipoxygenase antibody at -20oC.

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