EpCAM Antibody for IHC Tissue Microarray (TMA). Immunohistochemistry analysis of Epithelial cell adhesion molecule EPCAM, also known as CD326, in formalin-fixed paraffin-embedded human normal and cancer tissue microarrays using recombinant rabbit monoclonal EpCAM antibody clone MSVA-326R. Tissue microarray (TMA) staining with HRP-DAB brown chromogen demonstrates strong membranous localization in epithelial structures, including colon mucosa, small intestine, stomach, prostate, and endometrial glands, while non-epithelial tissues such as skeletal muscle, lymphoid tissues, and stromal compartments show minimal to absent staining. Within tumor tissue microarrays, robust membranous positivity is observed across multiple epithelial malignancies including colorectal adenocarcinoma, breast carcinoma, lung adenocarcinoma, ovarian carcinoma, pancreatic carcinoma, and urothelial carcinoma, while mesenchymal tumors and non-epithelial malignancies remain largely negative. Evaluation across large TMA panels enables direct comparison of EPCAM expression across diverse tissue types under standardized conditions. The observed staining patterns align with reported EPCAM expression profiles in the Human Protein Atlas and support its use in identifying epithelial-derived tumor cells.