Zebrafish Hsd3b1 Antibody (RZ1198)

Description

3-beta-hydroxysteroid dehydrogenase type 1 (Hsd3b1) is a key enzyme in the biosynthesis of steroid hormones, catalyzing the conversion of delta-5-3-beta-hydroxysteroids to delta-4-ketosteroids. In zebrafish (Danio rerio), Hsd3b1 plays a crucial role in the production of glucocorticoids, mineralocorticoids, androgens, and estrogens, and is essential for proper steroidogenic tissue function, including that of the gonads and interrenal gland (the fish analog of the adrenal cortex).

Zebrafish hsd3b1 is expressed in steroidogenic tissues during development and in adult stages, where it supports endocrine functions related to stress response, reproduction, and growth. The enzyme is highly conserved across vertebrates, making zebrafish a valuable model for studying steroid biosynthesis, hormonal regulation, and the effects of endocrine-disrupting chemicals (EDCs).

Because of its involvement in hormone production and its responsiveness to physiological and environmental signals, zebrafish Hsd3b1 is widely used in research on developmental endocrinology, reproductive biology, and toxicology.

Application Notes

Optimal dilution of the Zebrafish Hsd3b1 antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Hsd3b1 recombinant protein (amino acids F16-K374) was used as the immunogen for the Zebrafish Hsd3b1 antibody.

Storage

After reconstitution, the Zebrafish Hsd3b1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.